Epistaxis and Gastrointestinal Bleeding: Manifestations of Osler-Weber-Rendu Syndrome

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Marisa Isabel de Sousa Ferreira Rosete - Corresponding Author

Marisa Isabel de Sousa Ferreira Rosete [rosete.marisa@gmail.com]
Rua da Telecom nº 28 - Silveirinho 3360-259 São Pedro de Alva, Portugal

Margarida Gaudêncio
Susana Magalhães
Fernando Ferraz e Sousa
Amélia Pereira

Abstract

Hereditary hemorrhagic telangiectasia, also called Osler-Weber-Rendu syndrome is an autosomal dominant vascular disorder with a variety of clinical manifestations. Among the most common are epistaxis, gastrointestinal bleeding, iron deficiency anemia, mucocutaneous telangiectasia and arteriovenous malformations.
The authors propose to present the clinical case of a patient, male, 78-year-old with decompensated heart failure, iron deficiency anemia requiring transfusion and multiple telangiectasia. History of spontaneous and recurrent epistaxis since youth and recent episode of gastrointestinal bleeding. During hospitalization, he presented an episode of severe epistaxis and hematochezias, complicated by hypovolemic shock. The diagnosis of Osler-Weber-Rendu syndrome was admitted and he started hormone therapy. Prolonged hospitalization due to hemorrhagic and infectious complications, the patient died on the 30th day of hospitalization in the context of acute lung edema.
The case presented corresponds to hereditary hemorrhagic telangiectasia. However, its diagnosis was late, presenting an unfavorable evolution.

Keywords: Epistaxis; Gastrointestinal Hemorrhage; Telangiectasia, Hereditary Hemorrhagic

Article Details

1.
de Sousa Ferreira Rosete MI, Gaudêncio M, Magalhães S, Sousa FF e, Pereira A. Epistaxis and Gastrointestinal Bleeding: Manifestations of Osler-Weber-Rendu Syndrome. Gaz Med [Internet]. 2020 Sep. 30 [cited 2022 Jan. 21];7(3). Available from: https://gazetamedica.pt/index.php/gazeta/article/view/375
Section
CLINICAL CASE

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