Just a Tongue Anomaly or Something More?

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Cristina Aguiar - Corresponding Author

Cristina Aguiar [cristinaaguiar16@gmail.com]
Rua Conceição Fernandes, s/n, 4434-502 Vila Nova de Gaia, Porto, Portugal

Nuno Medeiros
Leandro Ribeiro
Artur Condé


A 54-year-old woman with a past history of breast and uterine cancer, appeared at the Emergency Room with a six-month history of fatigue, weight loss (> 12 kg), lower limbs swelling and dysphagia due to progressive tongue enlargement. ENT examination demonstrated macroglossia (Fig. 1-A), that was confirmed by computed tomography (CT) scan (Fig. 1-B). Laboratory tests complemented with image findings showed the presence of a restrictive cardiomyopathy and a nephrotic syndrome. The abdominal fat biopsy with immunofixation electrophoresis was positive for light-chain amyloidosis. The patient began chemotherapy treatment with bortezomib, dexamethasone and cyclophosphamide, completing four cycles of treatment with frank tongue reduction. The patient died 5 months after the diagnosis.[...]

Keywords: Deglutition Disorders; Immunoglobulin Light-chain Amyloidosis; Macroglossia

Article Details

Aguiar C, Medeiros N, Ribeiro L, Condé A. Just a Tongue Anomaly or Something More?. Gaz Med [Internet]. 2022 Mar. 15 [cited 2022 Nov. 30];9(2):184-5. Available from: https://gazetamedica.pt/index.php/gazeta/article/view/554

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