A Case of Alloimune Thrombocytopenia with Neutropenia Um Caso de Trombocitopenia Neonatal com Neutropenia

Abstract

Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe perinatal thrombocytopenia, results from feto-maternal platelet antigen incompatibility leading to the production of maternal antibodies and destruction of fetal platelets during pregnancy. Correlation between anti-HLA alloantibodies and neonatal neutropenia is extremely rare, in part because of reduced expression of leukocyte HLAs in neonates. Because both platelets and neutrophils exhibit HLAs, it is possible for HLA antibodies to cause both neonatal alloimune neutropenia and Neonatal alloimmune thrombocytopenia. Combined alloimune cytopenias are rare. We report a case of Neonatal alloimmune thrombocytopenia associated with neutropenia alloimune.

Received: 30/09/2017 - Accepted: 18/10/2017