A Case of Alloimune Thrombocytopenia with Neutropenia Um Caso de Trombocitopenia Neonatal com Neutropenia

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Sónia Marques - Corresponding Author

Rua Mário Botas, 1998-018 Lisboa, Portugal

 

Mafalda Lucas
Ana Rodrigues
Ana Rute Ferreira
Glória Carvalhosa
Ana Serrão Neto

Abstract

Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe perinatal thrombocytopenia, results from feto-maternal platelet antigen incompatibility leading to the production of maternal antibodies and destruction of fetal platelets during pregnancy. Correlation between anti-HLA alloantibodies and neonatal neutropenia is extremely rare, in part because of reduced expression of leukocyte HLAs in neonates. Because both platelets and neutrophils exhibit HLAs, it is possible for HLA antibodies to cause both neonatal alloimune neutropenia and Neonatal alloimmune thrombocytopenia. Combined alloimune cytopenias are rare. We report a case of Neonatal alloimmune thrombocytopenia associated with neutropenia alloimune.


Received: 30/09/2017 - Accepted: 18/10/2017

Keywords: Neutropenia; Thrombocytopenia, Neonatal Alloimmune

Article Details

1.
Marques S, Lucas M, Rodrigues A, Ferreira AR, Carvalhosa G, Neto AS. A Case of Alloimune Thrombocytopenia with Neutropenia: Um Caso de Trombocitopenia Neonatal com Neutropenia. Gaz Med [Internet]. 2018 Feb. 20 [cited 2024 Sep. 8];4(4). Available from: https://gazetamedica.pt/index.php/gazeta/article/view/84
Section
CLINICAL CASE

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